Water → HCID 66590077, compound

Participants

Reaction Steps

Into a 10 mL round bottom flask was added 19C (200 mg, 302 μmol) and THF (3 mL). Triphenylphosphine (166 mg, 634 μmol) and water (112 mg, 6.22 mmol) was added and the flask was fitted with a reflux condenser and nitrogen inlet. The mixture was refluxed for three hours. Solvent was removed under vacuum and the residue was purified by preparatory LCMS to give 19D (40 mg, 21%). ESI-MS:m/z 734.2 (M+H)+.

Provenance & Evidence