Acetyl chloride → 1-Chloro-4-(chloro-prop-2-ynyloxy-methyl)-benzene

Participants

Reaction Conditions

Reaction Steps

1-(Bis-prop-2-ynyloxy-methyl)-4-chloro-benzene (11.7 g) is added to acetyl chloride (19.9 g) and thionyl chloride (0.2 ml) over 1 hour. The temperature is maintained at 20° C. by occasionally cooling. The reaction mixture is stirred at room temperature for 20 hours. The reaction mixture is evaporated at 20-30° C. using vacuum. 1-Chloro-4-(chloro-prop-2-ynyloxy-methyl)-benzene (13.4 g) is obtained as oil.

Provenance & Evidence