反应详情

温度

1 °C

A mixture of chlorobenzene (1400 g) and trichloro-acetaldehyde (384 g) is stirred at 0-2° C. Aluminium chloride (274 g) is added in portions over 110 minutes at the same temperature. Occasionally cooling is necessary. The reaction mixture is stirred at 0-5° C. for 5 hours. The reaction mixture is poured into ice/water (3000 g). The organic phase is separated, washed three times with water (500 g each), dried (sodium sulfate) and evaporated. 2,2,2-Trichloro-1-(4-chloro-phenyl)-ethanol is obtained as oil.

1. temperatureOccasionally cooling
2. stirringThe reaction mixture is stirred at 0-5° C. for 5 hours
3. customThe organic phase is separated
4. washwashed three times with water (500 g each)
5. dry with materialdried (sodium sulfate)
6. customevaporated