反应详情

Next, 0.68 g (1.03 mmol) of benzyl 2-(N-benzyloxycarbonylamino)-4-{[3-(2-benzyloxycarbonylethyl)phenyl](methyl)phosphono}butanoate was dissolved in 50 mL of a solvent mixture of methanol and water at 4:1 and mixed with 240 mg of 5% palladium-carbon, and hydrogen gas was introduced at room temperature for 5 hours. Thereafter, the palladium-carbon was removed by Celite filtration and the filtrate was vacuum-concentrated and the residue was freeze-dried from water to obtain 2-amino-4-{[3-(2-carboxyethyl)phenyl](methyl)phosphono}butanoic acid (0.31 g, yield 86%) as a colorless solid.

1. additionwas introduced at room temperature for 5 hours
2. customThereafter, the palladium-carbon was removed by Celite filtration
3. concentrationthe filtrate was vacuum-concentrated
4. dry with materialthe residue was freeze-dried from water