反应详情

Next, 0.64 g (1.06 mmol) of benzyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-(diphenylphosphono)butanoate was dissolved in 20 mL of acetic acid and mixed with 86 mg of 10% palladium-carbon and hydrogen gas was introduced at room temperature for 2 hours. Thereafter, the palladium-carbon was removed by Celite filtration and the filtrate was vacuum-concentrated, and the residue was crystallized from a solvent mixture of acetonitrile and water to obtain 2-amino-4-(diphenylphosphono)butanoic acid (0.13 g, yield 37%) as a colorless solid.

1. additionwas introduced at room temperature for 2 hours
2. customThereafter, the palladium-carbon was removed by Celite filtration
3. concentrationthe filtrate was vacuum-concentrated
4. customthe residue was crystallized from a solvent mixture of acetonitrile and water