反应详情

NBS (2.52 g, 14.7 mmol) is added to a stirred solution of N-[5-(4-amino-phenyl)-4-methyl-thiazol-2-yl]-acetamide (Example 1a) (3.5 g, 14.7 mmol) in dry dimethylsulphoxide (50 ml) at 10° C. After 10 minutes the solution is diluted with water (200 ml) and the resulting precipitate is removed by filtration. Crystallisation from ethyl acetate-methanol affords the title compound. MH+ (TOF, MS ES+): 325.9, 328.9

1. customthe resulting precipitate is removed by filtration
2. customCrystallisation from ethyl acetate-methanol