Ethyl 3-isocyanatopropanoate → 3-{3-[5-(4-Dimethylsulfamoyl-phenyl)-4-methyl-thiazol-2-yl]-ureido}-propionic acid ethyl ester

Participants

Reaction Steps

Using 4-(2-amino-4-methyl-thiazol-5-yl)-N,N-dimethyl-benzenesulfonamide (Example 24a) (0.083 g, 0.28 mmol) and replacing ethyl isocyanatoacetate with ethyl 3-isocyanatopropionate (0.05 ml, 0.34 mmol) in the above reaction affords the title compound.

Provenance & Evidence