Iodine → HCID 85861728, compound

HRID 1092953Notes

Reaction equation

HRID 1092953 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10](=O)[CH3:11])=[CH:5][CH:4]=1.[C:13]([NH:16][C:17]([NH2:19])=[S:18])(=[O:15])[CH3:14].II>N1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:18][C:17]([NH:16][C:13](=[O:15])[CH3:14])=[N:19][C:10]=2[CH3:11])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 807IodineHCID 312311-(p-Methoxyphenyl)-2-propanoneHCID 2723593Acetylthiourea

Product 1

HCID 85861728HCID 85861728, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

4-methoxyphenylacetone (10 g, 60.9 mmol), N-acetylthiourea (7.2 g, 60.9 mmol), iodine (15.46 g, 60.9 mmol) in pyridine (50 ml) are stirred at 70° C. for 16 hours. The mixture is concentrated and the residue is purified by chromatography on silica with hexane-ethyl acetate (1:1) to give the titled compound.

Workup

  1. concentrationThe mixture is concentrated
  2. customthe residue is purified by chromatography on silica with hexane-ethyl acetate (1:1)

Sources & evidence

ORD record
ord-92420272e8ae460f94bae787b3da40d2
Source dataset
uspto-grants-2012_03
Patent number
US08129541B2

Reaction notes

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