1-(p-Chlorophenyl)acetone → N-[5-(4-Chloro-3-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide

HRID 1092958Notes

Reaction equation

HRID 1092958 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][C:11]([NH:13][C:14](=[O:16])[CH3:15])=[N:10][C:9]=2[CH3:17])=[CH:4][C:3]=1[S:18]([CH3:21])(=[O:20])=[O:19].[Cl:22]C1C=CC(CC(=O)C)=CC=1>>[Cl:22][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][C:11]([NH:13][C:14](=[O:16])[CH3:15])=[N:10][C:9]=2[CH3:17])=[CH:4][C:3]=1[S:18]([CH3:21])(=[O:20])=[O:19]

Participants

3

Reactant 2

HCID 796991-(p-Chlorophenyl)acetoneHCID 86598409N-[5-(4-Fluoro-3-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide

Product 1

HCID 57831148N-[5-(4-Chloro-3-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide

Procedure

The title compound is prepared following the same route as N-[5-(4-Fluoro-3-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide (Example 47) by replacing 4-fluorophenyl acetone with 4-chlorophenyl acetone.

Sources & evidence

ORD record
ord-6fc09a639feb4c1d893f33532176f665
Source dataset
uspto-grants-2012_03
Patent number
US08129541B2

Reaction notes

Loading…