Acetylthiourea → N-[4-Methyl-5-(3-nitro-phenyl)-thiazol-2-yl]-acetamide

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-bromo-1-(3-nitro-phenyl)-propan-2-one (Example 49a) (0.5 g, 1.94 mmol) and N-acetylthiourea (0.23 g, 1.94 mmol) in ethanol (10 ml) is stirred at 70° C. for 2 hours. After cooling the reaction to room temperature, the precipitated product is removed by filtration and dried under vacuum to give the titled compound (0.28 g).

Provenance & Evidence