HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(p-Methoxyphenyl)-2-propanone → N-[5-(4-Fluoro-3-sulfamoyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(p-Methoxyphenyl)-2-propanone | HCID 31231 | — |
| Reactant | (4-Fluorophenyl)acetone | HCID 521187 | — |
| Reactant | 2-Fluoro-5-(2-oxo-propyl)-benzenesulfonyl chloride | HCID 85861732 | — |
| Reactant | N-[5-(4-Methoxy-3-sulfamoyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide | HCID 86598407 | — |
| Product | N-[5-(4-Fluoro-3-sulfamoyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide | HCID 85861686 | — |
Reaction Steps
The title compound is prepared from 4-fluorophenyl acetone via 2-fluoro-5-(2-oxo-propyl)-benzenesulfonyl chloride (Example 47a) following an identical sequence of reactions used for the synthesis of N-[5-(4-methoxy-3-sulfamoyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide (Example 30) from 4-methoxyphenyl acetone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08129541B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-fe1143120d714b9796a9629dd6cf8e01 |
| Source note | uspto-grants-2012_03 |