Sodium Hydroxide → HCID 86598410, compound

HRID 1092964Notes

Reaction equation

HRID 1092964 reaction equation
[OH-].[Na+].C([O:5][C:6](=[O:28])[CH2:7][NH:8][C:9]([NH:11][C:12]1[S:13][C:14]([C:18]2[CH:23]=[CH:22][C:21]([S:24]([CH3:27])(=[O:26])=[O:25])=[CH:20][CH:19]=2)=[C:15]([CH3:17])[N:16]=1)=[O:10])C>CO>[CH3:27][S:24]([C:21]1[CH:22]=[CH:23][C:18]([C:14]2[S:13][C:12]([NH:11][C:9](=[O:10])[NH:8][CH2:7][C:6]([OH:28])=[O:5])=[N:16][C:15]=2[CH3:17])=[CH:19][CH:20]=1)(=[O:25])=[O:26]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86598411HCID 86598411, compound

Product 1

HCID 86598410HCID 86598410, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Aqueous sodium hydroxide (2M, 0.5 ml) is added to a stirred solution of {3-[5-(4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-ureido}-acetic acid ethyl ester (Example 60) (0.14 g, 0.00035 mmol) in methanol (2 ml). After stirring at room temperature for 18 hours the solvent is removed and dilute HCl is added. The resulting yellow solid is removed by filtration and recrystallised from ethanol to afford the title compound. MH+ 370.0

Workup

  1. customis removed
  2. additiondilute HCl is added
  3. customThe resulting yellow solid is removed by filtration
  4. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-2ccd5ef4eada4301a4e341a6a7fadf98
Source dataset
uspto-grants-2012_03
Patent number
US08129541B2

Reaction notes

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