HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1092979Generated: October 31, 2026
Phosgene → 5-(3-Fluoro-4-methanesulfonyl-phenyl)-2-isocyanato-4-methyl-thiazole
https://huagongshe.com/reaction/1092979
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | 5-(3-Fluoro-4-(methylsulfonyl)phenyl)-4-methylthiazol-2-amine | HCID 57351277 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 5-(3-Fluoro-4-methanesulfonyl-phenyl)-2-isocyanato-4-methyl-thiazole | HCID 85861648 | — |
Reaction Steps
5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine (Example 72) (1.74 mmol, 0.5 g) is added to acetonitrile (15 ml) and treated with phosgene (20% solution in toluene, 6.99 mmol, 3.7 ml). The reaction mixture is heated to reflux (85° C.) for 30 minutes. After cooling to room temperature the solvent is removed in vacuo to leave 5-(3-fluoro-4-methanesulfonyl-phenyl)-2-isocyanato-4-methyl-thiazole as an orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08129541B2 |
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| Source dataset | uspto-grants-2012_03 |
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| ORD ID | ord-5ff5a80d4c784c1a9899e40ed1deb7f1 |
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| Source note | uspto-grants-2012_03 |
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