HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium methanesulfinate → N-[5-(3,4-Bis-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium methanesulfinate | HCID 2733271 | — |
| Reactant | 3-Fluoro-4-methanesulfonylbenzaldehyde | HCID 21251732 | — |
| Reactant | N-[5-(3-fluoro-4-methylsulfonylphenyl)-4-methyl-1,3-thiazol-2-yl]acetamide | HCID 57351276 | — |
| Product | N-[5-(3,4-Bis-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide | HCID 85861727 | — |
Reaction Steps
This is isolated as a minor by product in the synthesis of N-[5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide (Example 64) when excess methane sulfinic acid sodium salt is added in the first step of the synthesis (64a). The resulting aldehyde is converted into the title compound by the procedure described in parts 64b-d.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08129541B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-e7cee021a9564acb810c143eb8c7f07b |
| Source note | uspto-grants-2012_03 |