Acetamide, N-[5-[3-(1H-imidazol-1-YL)-4-(methylsulfonyl)phenyl]-4-methyl-2-thiazolyl]- → N-[5-(3-Imidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-propionamide

HRID 1092990Notes

Reaction equation

HRID 1092990 reaction equation
[N:1]1([C:6]2[CH:7]=[C:8]([C:16]3[S:20][C:19]([NH:21][C:22](=[O:24])[CH3:23])=[N:18][C:17]=3[CH3:25])[CH:9]=[CH:10][C:11]=2[S:12]([CH3:15])(=[O:14])=[O:13])[CH:5]=[CH:4][N:3]=[CH:2]1.F[C:27]1C=C(C2SC(NC(=O)C)=NC=2C)C=CC=1S(C)(=O)=O.FC1C=C(C2SC(NC(=O)CC)=NC=2C)C=CC=1S(C)(=O)=O>>[N:1]1([C:6]2[CH:7]=[C:8]([C:16]3[S:20][C:19]([NH:21][C:22](=[O:24])[CH2:23][CH3:27])=[N:18][C:17]=3[CH3:25])[CH:9]=[CH:10][C:11]=2[S:12]([CH3:15])(=[O:14])=[O:13])[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 3

HCID 53429448Acetamide, N-[5-[3-(1H-imidazol-1-YL)-4-(methylsulfonyl)phenyl]-4-methyl-2-thiazolyl]-HCID 57351276N-[5-(3-fluoro-4-methylsulfonylphenyl)-4-methyl-1,3-thiazol-2-yl]acetamideHCID 86598426N-[5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-propionamide

Product 1

HCID 86598427N-[5-(3-Imidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-propionamide

Procedure

The title compound is prepared via an analogous procedure to N-[5-(3-imidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide (Example 80) by replacing N-[5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide in this example with N-[5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-propionamide (159).

Sources & evidence

ORD record
ord-0c5e49849f994f7b929f1b459a211187
Source dataset
uspto-grants-2012_03
Patent number
US08129541B2

Reaction notes

Loading…