6-(Morpholino)pyridin-3-amine → 1-[5-(4-Chloro-3-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-3-(6-morpholin-4-yl-pyridin-3-yl)-urea

HRID 1092997Notes

Reaction equation

HRID 1092997 reaction equation
FC1C=C(C2SC(N[C:18](NCCO)=[O:19])=NC=2C)C=CC=1S(C)(=O)=O.[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]2[S:36][C:35]([NH2:37])=[N:34][C:33]=2[CH3:38])=[CH:28][C:27]=1[S:39]([CH3:42])(=[O:41])=[O:40].[O:43]1[CH2:48][CH2:47][N:46]([C:49]2[N:54]=[CH:53][C:52]([NH2:55])=[CH:51][CH:50]=2)[CH2:45][CH2:44]1>>[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]2[S:36][C:35]([NH:37][C:18]([NH:55][C:52]3[CH:53]=[N:54][C:49]([N:46]4[CH2:47][CH2:48][O:43][CH2:44][CH2:45]4)=[CH:50][CH:51]=3)=[O:19])=[N:34][C:33]=2[CH3:38])=[CH:28][C:27]=1[S:39]([CH3:42])(=[O:40])=[O:41]

Participants

4

Reactant 3

HCID 1040596-(Morpholino)pyridin-3-amineHCID 578311165-[4-Chloro-3-(methylsulfonyl)phenyl]-4-methyl-1,3-thiazol-2-amineHCID 865984211-[5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-3-(2-hydroxy-ethyl)-urea

Product 1

HCID 865984301-[5-(4-Chloro-3-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-3-(6-morpholin-4-yl-pyridin-3-yl)-urea

Procedure

The title compound is prepared by the same procedure as 1-[5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-3-(2-hydroxy-ethyl)-urea (Example 88) replacing 5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine (Example 72) with 5-(4-chloro-3-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine (Example 83) and by replacing 2-aminoethanol (part 88b) with 6-morpholinopyridin-3-amine.

Sources & evidence

ORD record
ord-abe4e54918f64251ba5406a4aa5b6d1b
Source dataset
uspto-grants-2012_03
Patent number
US08129541B2

Reaction notes

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