Dimethylamine → N-[5-(3,5-Dichloro-4-dimethylsulfamoyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide

HRID 1093004Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C:13]2[S:17][C:16]([NH:18][C:19](=[O:21])[CH3:20])=[N:15][C:14]=2[CH3:22])[CH:5]=[C:6]([Cl:12])[C:7]=1[S:8](=[O:11])(=[O:10])N.[CH3:23][NH:24][CH3:25]>>[Cl:12][C:6]1[CH:5]=[C:4]([C:13]2[S:17][C:16]([NH:18][C:19](=[O:21])[CH3:20])=[N:15][C:14]=2[CH3:22])[CH:3]=[C:2]([Cl:1])[C:7]=1[S:8](=[O:10])(=[O:11])[N:24]([CH3:25])[CH3:23]

Participants

Reactant 2

HCID 674Dimethylamine

HCID 86598402N-[5-(3,5-Dichloro-4-sulfamoyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide

Product 1

HCID 86598438N-[5-(3,5-Dichloro-4-dimethylsulfamoyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide

Procedure

The title compound is prepared by an analagous procedure to N-[5-(3,5-dichloro-4-sulfamoyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide (Example 6) by replacing ammonia with dimethylamine.

Sources & evidence

ORD record: ord-e271c740e0254c7ab8e03362bca45c5d
Source dataset: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08129541B2

Reaction notes

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