4-(2-Amino-4-methyl-thiazol-5-yl)-2,6-dichloro-benzenesulfonamide → 4-(2-Amino-4-methyl-thiazol-5-yl)-2,6-dichloro-N,N-dimethyl-benzenesulfonamide

HRID 1093005Notes

Reaction equation

HRID 1093005 reaction equation
NC1SC(C2C=C(Cl)C(S(N)(=O)=O)=C(Cl)C=2)=C(C)N=1.[Cl:20][C:21]1[CH:22]=[C:23]([C:34]2[S:38][C:37]([NH:39]C(=O)C)=[N:36][C:35]=2[CH3:43])[CH:24]=[C:25]([Cl:33])[C:26]=1[S:27](=[O:32])(=[O:31])[N:28]([CH3:30])[CH3:29]>>[NH2:39][C:37]1[S:38][C:34]([C:23]2[CH:24]=[C:25]([Cl:33])[C:26]([S:27]([N:28]([CH3:30])[CH3:29])(=[O:32])=[O:31])=[C:21]([Cl:20])[CH:22]=2)=[C:35]([CH3:43])[N:36]=1

Participants

3

Reactant 2

HCID 858616664-(2-Amino-4-methyl-thiazol-5-yl)-2,6-dichloro-benzenesulfonamideHCID 86598438N-[5-(3,5-Dichloro-4-dimethylsulfamoyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide

Product 1

HCID 865984394-(2-Amino-4-methyl-thiazol-5-yl)-2,6-dichloro-N,N-dimethyl-benzenesulfonamide

Procedure

The title compound is prepared by the same procedure as 4-(2-amino-4-methyl-thiazol-5-yl)-2,6-dichloro-benzenesulfonamide (Example 26) by replacing N-[5-(3,5-dichloro-4-sulfamoyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide (Example 6) with N-[5-(3,5-dichloro-4-dimethylsulfamoyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide (171a).

Sources & evidence

ORD record
ord-5498629bfbba4d08b8768ea3ebdc064a
Source dataset
uspto-grants-2012_03
Patent number
US08129541B2

Reaction notes

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