2-Fluoro-5-formylbenzonitrile → HCID 70695188, compound

HRID 1093012Notes

Reaction equation

HRID 1093012 reaction equation
F[C:2]1[CH:3]=[C:4]([C:12]2[S:16][C:15]([NH:17][C:18](=[O:20])[CH3:19])=[N:14][C:13]=2[CH3:21])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:11])(=[O:10])=[O:9].FC1C=CC(C=O)=CC=1[C:25]#[N:26]>>[C:25]([C:2]1[CH:3]=[C:4]([C:12]2[S:16][C:15]([NH:17][C:18](=[O:20])[CH3:19])=[N:14][C:13]=2[CH3:21])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:11])(=[O:10])=[O:9])#[N:26]

Participants

3

Reactant 2

HCID 27695822-Fluoro-5-formylbenzonitrileHCID 57351276N-[5-(3-fluoro-4-methylsulfonylphenyl)-4-methyl-1,3-thiazol-2-yl]acetamide

Product 1

HCID 70695188HCID 70695188, compound

Procedure

The titled compound was prepared by an identical procedure to N-[5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide (Example 64) replacing 3,4-difluorobenzaldehyde in this procedure with 2-fluoro-5-formylbenzonitrile.

Sources & evidence

ORD record
ord-e269957a3e02481685c7a661b13ebaa0
Source dataset
uspto-grants-2012_03
Patent number
US08129541B2

Reaction notes

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