Bromine → 1-Bromo-1-(3-methanesulphonyl-phenyl)-propanone

HRID 1093015Notes

Reaction equation

HRID 1093015 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([CH2:11][C:12](=[O:14])[CH3:13])[CH:8]=[CH:9][CH:10]=1)(=[O:4])=[O:3].[Br:15]Br>O1CCOCC1>[Br:15][CH:11]([C:7]1[CH:8]=[CH:9][CH:10]=[C:5]([S:2]([CH3:1])(=[O:3])=[O:4])[CH:6]=1)[C:12](=[O:14])[CH3:13]

Participants

4

Reactant 2

HCID 24408BromineHCID 665884811-(3-(Methylsulfonyl)phenyl)propan-2-one

Product 1

HCID 858616531-Bromo-1-(3-methanesulphonyl-phenyl)-propanone

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A stirred solution of 1-(3-methanesulphonyl-phenyl)-propan-2-one (176b) (0.25 g, 1.18 mmol) in dioxane (10 ml) at 5° C. is treated with bromine (0.131 g, 0.82 mmol) added in two portions. The reaction is stirred and allowed to warm up to room temperature. The solvent is removed in vacuo to yield an orange oil of the titled compound.

Workup

  1. additionadded in two portions
  2. customThe solvent is removed in vacuo

Sources & evidence

ORD record
ord-7322d988ca48436db43a24f062528d8b
Source dataset
uspto-grants-2012_03
Patent number
US08129541B2

Reaction notes

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