Ammonia → [5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-urea

HRID 1093019Notes

Reaction equation

HRID 1093019 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:12]2[S:16][C:15]([NH:17][C:18]([NH:20]CCO)=[O:19])=[N:14][C:13]=2[CH3:24])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:11])(=[O:10])=[O:9].N>>[F:1][C:2]1[CH:3]=[C:4]([C:12]2[S:16][C:15]([NH:17][C:18]([NH2:20])=[O:19])=[N:14][C:13]=2[CH3:24])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:11])(=[O:9])=[O:10]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 865984211-[5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-3-(2-hydroxy-ethyl)-urea2×

Product 1

HCID 57872135[5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-urea

Procedure

The title compound is prepared by the same procedure as -[5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-3-(2-hydroxy-ethyl)-urea (Example 88) by replacing 2-aminoethanol (part 88b) in this example with ammonia.

Sources & evidence

ORD record
ord-d557caa9554448728f4678d72db169f2
Source dataset
uspto-grants-2012_03
Patent number
US08129541B2

Reaction notes

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