Hydroxylamine → HCID 76637589, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of benzyl cyano(3-(hydroxymethyl)cyclopentyl)methyl(methyl)carbamate (0.540 g, 1.79 mmol) in ethanol (20 mL) was added 50% aqueous solution of hydroxylamine (0.07 mL, 2.15 mmol). The reaction mixture was stirred at 60° C. for 18 hours. The solvent was removed in vacuo to afford 0.610 g (76% yield) of title compound 1H NMR (400 MHz, CDCl3) δ ppm 7.33-7.43 (5 H, m), 7.14-7.23 (2 H, m), 5.18 (2 H, br s), 4.87-4.93 (1 H, m), 4.24 (1 H, m), 3.49-3.60 (2 H, m), 2.83-2.94 (3 H, br s), 2.60-2.71 (1 H, m), 2.11-2.49 (2 H, m), 1.60-2.11 (3 H, m), 1.25-1.55 (2 H, m). (+ESI, M+H+) 2 peaks m/z 336.

Provenance & Evidence