8-Oxa-3-aza-bicyclo(3.2.1)octane hydrochloride → 4-(4-(3,7-Dioxa-9-azabicyclo[3.3.1]nonan-9-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)aniline

Participants

Role	Name	HCID	Charge
Reactant	8-Oxa-3-aza-bicyclo(3.2.1)octane hydrochloride	HCID 21983536	—
Reactant	4-[4-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-1-(2,2,2-trifluoro-ethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-phenylamine	HCID 57424636	—
Reactant	9-(6-(4-nitrophenyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-3,7-dioxa-9-azabicyclo[3.3.1]nonane	HCID 66589004	—
Product	4-(4-(3,7-Dioxa-9-azabicyclo[3.3.1]nonan-9-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)aniline	HCID 66588944	—

Reaction Steps

4-(4-(3,7-Dioxa-9-azabicyclo[3.3.1]nonan-9-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)aniline was prepared from 9-(6-(4-nitrophenyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-3,7-dioxa-9-azabicyclo[3.3.1]nonane according to the method used for 4-[4-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-1-(2,2,2-trifluoro-ethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-phenylamine, except in step 5,3,7-dioxa-9-azabicyclo[3.3.1]nonane formate replaced 8-oxa-3-aza-bicyclo[3.2.1]octane hydrochloride.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08129371B2
Source dataset	uspto-grants-2012_03
ORD ID	ord-135260ad51bb4f419777a01862dc9b4f
Source note	uspto-grants-2012_03