HCID 68732807, compound → HCID 91022940, compound

Participants

Reaction Steps

Methyl{4-[1-(1,4-dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl}carbamate (0.2 g, 0.38 mmol) was dissolved in conc. HCl (2.0 mL) and stirred at room temperature for 1 hr. The reaction was cooled in an ice bath and basified with 10N. sodium hydroxide to precipitate a white solid. The solid was filtered and washed with water and purified by Gilson HPLC to give the desired product (93 mg) MS m/z=477 (M+H).

Provenance & Evidence