Acetic Acid → HCID 57424595, compound

Participants

Reaction Steps

To a solution of 1-methyl-3-{4-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1-(4-oxocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl}urea (65 mg) in DCE (2.0 mL) was added excess N-methylpiperizine, acetic acid (0.012 mL) and excess sodium triacetoxyborohydride. The mixture was stirred at room temperature overnight. The reaction was quenched with water and the organics were separated and concentrated under nitrogen and purified by Gilson HPLC to give the desired product (56 mg) MS m/z=560.3 (M+H).

Provenance & Evidence