Water → HCID 66588933, compound

Participants

Reaction Steps

To a solution of 1-ethyl-6-(4-nitrophenyl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidine (7.9 g)(20.8 mmol) in DMF (140 mL) was added N-bromosuccinimide (18.5 g) and heated to 85 C for 24 hr. The reaction was cooled and poured into water (1.0 L) to precipitate tan solids. The solids were filtered off and washed with water. The crude solid was purified by silica gel chromatography (EtOAc/Hexanes) to give 2.8 g of a yellow solid. MS m/z=459.2 (M+H)

Provenance & Evidence