Water → HCID 66588946, compound

Participants

Reaction Steps

To a solution of 3-bromo-1-ethyl-6-(4-nitrophenyl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidine (100 mg)(0.21 mmol) in toluene/EtOH (1:1) (2.0 mL) was added Pd(PPh3)4 (12 mg) (10 mol %), aqueous sodium bicarbonate solution (2.0 M) (0.135 mL) and 3-pyridine boronic acid (32 mg) (0.26 mmol). The reaction was heated in the microwave for 20 minutes at 140 C. The reaction was cooled and added water and then extracted three times with EtOAc. Organics were dried (MgSO4) and filtered off through a pad of Magnesol and concentrated in vacuo. to give a yellow oil 100 mg. MS m/z=458 (M+H)

Provenance & Evidence