HCID 57424615, compound → HCID 57424616, compound

Participants

Reaction Steps

To a solution of 1-{4-[3-(1,2-dihydroxyethyl)-1-ethyl-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl}-3-methylurea (158 mg) (0.34 mmol) in DCM:THF (2:1) (6.0 mL) was added excess sodium NaIO4 on silica gel and the mixture was stirred for 1 hr. at room temperature. The insoluble material was filtered off and the organics were dried (Na2SO4) and filtered off through Magnesol and then concentrated in vacuo. to give a white solid that was collected with diethyl ether to give 110 mg. MS m/z=436.2.2 (M+H).

Provenance & Evidence