4-Aminophenol → HCID 57424660, compound

Participants

Reaction Steps

30 mg (0.11 mmol) of 2-Chloro-4-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-thieno[3,2-d]pyrimidine was dissolved in 1 mL ethylene glycol. 0.5 mmol (54 mg) 4-aminophenol was added and the mixture was heated under microwave irradiation to 220 C (2×30 min). The mixture was diluted with 1 mL DMSO and purified by HPLC (TFA buffers) to give 25 mg (0.07 mmol, 66%) of the title compound.

Provenance & Evidence