1-(2-Bromoacetyl)pyrrolidine-2-carbonitrile → Oxan-2-yl 4-[[2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl]amino]bicyclo[2.2.2]octane-1-carboxylate

HRID 109331Notes

Reaction equation

HRID 109331 reaction equation
[Br:19][CH2:20][C:21](=[O:22])[N:23]1[CH:24]([C:28]#[N:29])[CH2:25][CH2:26][CH2:27]1.[NH2:1][C:2]12[CH2:3][CH2:4][C:5]([C:10](=[O:11])[O:12][CH:13]3[O:14][CH2:15][CH2:16][CH2:17][CH2:18]3)([CH2:6][CH2:7]1)[CH2:8][CH2:9]2>>[NH:1]([C:2]12[CH2:3][CH2:4][C:5]([C:10](=[O:11])[O:12][CH:13]3[O:14][CH2:15][CH2:16][CH2:17][CH2:18]3)([CH2:6][CH2:7]1)[CH2:8][CH2:9]2)[CH2:20][C:21](=[O:22])[N:23]1[CH:24]([C:28]#[N:29])[CH2:25][CH2:26][CH2:27]1

Participants

3

Reactant 2

HCID 178609191-(2-Bromoacetyl)pyrrolidine-2-carbonitrileHCID 231496982-Tetrahydropyranyl 4-aminobicyclo[2,2,2]octane-1-carboxylate

Product 1

HCID 23149692Oxan-2-yl 4-[[2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl]amino]bicyclo[2.2.2]octane-1-carboxylate

Sources & evidence

ORD record
ord-2a77f2c4263e47dfb49812331a6723d8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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