Water → N-(3-Pyrazolo[1,5-a]pyridin-3-yl-phenyl)-acetamide

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-bromo-pyrazolo[1,5-a]pyridine (197 mg, 1 mmol), (3-acetylaminophenyl)boronic acid (179 mg), K2CO3 (6 eq) and bis(tri-t-butylphosphine)palladium (0) (5 mg) in PhMe (1 ml), MeOH (1 ml), EtOH (1 ml), and H2O (1.8 ml) was stirred and heated at 155° C. in the microwave for 30 minutes. The mixture was partitioned between EtOAc/H2O. The layers were separated and the organic layer was dried, filtered and evaporated. The residue was crystallised from MeOH to give the title compound (50 mg). MS: [M+H]+ 252

Provenance & Evidence