P-Anisidine → HCID 66592614, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(3-Chloro-phenyl)-imidazo[1,2-a]pyridine (183 mg, 0.8 mmol), 4-Methoxy-phenylamine (200 mg, 1.6 mmol) and sodium tertbutoxide (195 mg, 2 mmol) in dry toluene (3 ml) was deoxygenated. 2′-(Dimethylamino)-2-biphenylyl-palladium(II) chloride dinorbornylphosphine complex (45 mg, 0.08 mmol) was added and the reaction mixture deoxygenated again, then heated at 110° C. for 2 h. The mixture was allowed to cool, then partitioned between CH2Cl2 and H2O and separated using a phase separating cartridge. The organic solvent was removed in vacuo and the residue purified by column chromatography, then preparative HPLC to give the desired compound (25 mg).

Provenance & Evidence