1-Hydroxybenzotriazole → N-biphenyl-4-yl-3-oxo-3-(4-o-tolylamino-piperidin-1-yl)-propionamide

Participants

Reaction Steps

To a stirred solution of N-biphenyl-4-yl-malonamic acid (0.1 g, 0.00038 mole) in DMF (1 mL) was added DIPEA (0.245 g, 0.0019 mole), HOBt (0.056 g, 0.00042 mole) and EDCI.HCl (0.145 g, 0.00076 mole). After 2 minutes piperidin-4-yl-o-tolyl-amine dihydrochloride (0.106 g, 0.00042 mole) was added and the resulting mixture was stirred for 16 hours. The reaction mixture was then diluted with cold water and the resulting precipitate was isolated by filtration. Purification by column chromatography using silica gel (60-120 mesh) (1% methanol in chloroform) afforded 0.04 g (25%) of N-biphenyl-4-yl-3-oxo-3-(4-o-tolylamino-piperidin-1-yl)-propionamide. LC-MS purity: 428.23 (M+1)+, 93.11%, 1H NMR (DMSO-d6): δ 7.7 (m, 6H), 7.5 (t, 2H), 7.3 (t, 1H), 7.2 (q, 2H), 6.65 (q, 2H), 4.5 (d, 1H), 4.0 (d, 1H), 3.6 (m, 1H), 3.5 (s, 2H), 3.3 (s, 1H), 3.0 (t, 1H), 2.2 (m, 3H), 2.1 (s, 2H), 1.5 (t, 2H).

Provenance & Evidence