HCID 57874431, compound → HCID 57874485, compound

Participants

Reaction Steps

To a solution of N-biphenyl-4-yl-3-[4-(2-nitro-phenoxy)-piperidin-1-yl]-3-oxo-propionamide (0.09 g, 0.00019 mole) in methanol (10 mL) was added 10% Pd/C (0.015 g) and the resulting mixture was stirred under an atmosphere of hydrogen for 30 minutes. The mixture was then filtered through celite, the celite was washed with methanol and the organic layers were concentrated under reduced pressure. The resulting residue was recrystallized from a mixture of hexane and chloroform to afford 0.025 g (29%) of 3-[4-(2-amino-phenoxy)-piperidin-1-yl]-N-biphenyl-4-yl-3-oxo-propionamide. LC-MS purity: 430.21 (M+1)+, 90.7%, 1H NMR (DMSO-d6): δ 7.7 (m, 6H), 7.4 (m, 2H), 7.3 (m, 1H), 6.8 (m, 1H), 6.6 (m, 2H), 6.5 (m, 1H), 4.6 (bs, 2H), 4.5 (bs, 1H), 3.8 (m, 2H), 3.5 (m, 4H), 2.0 (m, 2H), 1.8 (m, 2H).

Provenance & Evidence