HCID 178523508, compound → HCID 178523509, compound

Participants

Reaction Steps

10% Pd/C (50 mg) was added to a stirred solution of 5-(2-benzyloxy-phenyl)-1H-pyrazole-3-carboxylic acid {2-oxo-2-[4-(3-trifluoromethyl-phenoxy)-piperidin-1-yl]-ethyl}-amide (195 mg, 0.34 mmol) (prepared by method used for the synthesis of Intermediate 45) in methanol (30 mL) under inert atmosphere and stirred under H2 atmosphere with pressure for 3 hrs. The reaction mixture was filtered through celite, the celite was washed with methanol and the filtrate was concentrated under reduced pressure Washing with ethyl acetate afforded 58 mg (35% Yield) of 5-(2-hydroxy-phenyl)-1H-pyrazole-3-carboxylic acid {2-oxo-2-[4-(3-trifluoromethyl-phenoxy)-piperidin-1-yl]-ethyl}-amide. LC/MS [M+H]+: 489, 91.45%. 1H NMR (300 MHz, DMSO-d6): δ8.2 (m, 1H), 7.64 (d, 1H), 7.5 (t, 1H), 7.26 (t, 2H), 7.1 (m, 2H), 6.94 (m, 1H), 6.84 (t, 1H), 4.8 (m, 1H), 4.2 (d, 2H), 3.9 (m, 1H), 3.7 (m, 1H), 3.4 (m, 2H), 1.9 (m, 2H), 1.6 (m, 2H).

Provenance & Evidence