1-Benzyl-3-aminopyrrolidine → HCID 57874467, compound

Participants

Reaction Steps

Pd(OH)2 (80 mg) was added to a stirred solution of 1-(1-benzyl-pyrrolidin-3-yl)-1H-[1,2,3]triazole-4-carboxylic acid {2-oxo-2-[4-(3-trifluoromethyl-phenoxy)-piperidin-1-yl]-ethyl}-amide (prepared by the method used for the synthesis of Example 136, starting from 1-benzyl-3-aminopyrrolidine) (407 mg, 0.73 mmol) in MeOH (4 mL) in an inert atmosphere and stirring was continued under H2 gas atmosphere for 6 hrs. The reaction mixture was filtered through celite. The filtrate collected was concentrated under reduced pressure to afford 260 mg (80.2% Yield) of 1-pyrrolidin-3-yl-1H-[1,2,3]triazole-4-carboxylic acid {2-oxo-2-[4-(3-trifluoromethyl-phenoxy)-piperidin-1-yl]-ethyl}-amide. LC/MS [M+H]+: 467.19.

Provenance & Evidence