Hydrochloric Acid → HCID 66591622, compound

Participants

Reaction Steps

A mixture of 4-(4-{2-oxo-2-[4-(3-trifluoromethyl-phenoxy)-piperidin-1-yl]-ethylcarbamoyl}-[1,2,3]triazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (prepared by the method used for the synthesis of Example 136, starting from 1-Boc-4-aminopiperidine) (380 mg, 0.65 mmol) in dioxane.HCl (5 mL) was stirred at ambient temperature for 1 hr. The reaction mixture was concentrated under reduced pressure to get the crude solid which was purified by recrystallisation from a mixture of MeOH and diethyl ether to afford 252 mg (73.9% Yield) of 1-piperidin-4-yl-1H-[1,2,3]triazole-4-carboxylic acid {2-oxo-2-[4-(3-trifluoromethyl-phenoxy)-piperidin-1-yl]-ethyl}-amide hydrochloride.

Provenance & Evidence