HCID 178498978, compound → HCID 57998845, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6,8-dihydroxypyrido[2,3-b]pyrazine-7-carboxylic acid methyl ester (5.0 g) in concentrated hydrochloric acid (36% by weight in water) was added a few drops of concentrated sulfuric acid at ambient temperature. The reaction mixture was then heated to 100° C. for four hours. The reaction mixture was allowed to cool to ambient temperature and stored at ambient temperature for 16 hours. Then the reaction mixture was concentrated and dried under high vacuum to give 8-hydroxy-5H-pyrido[2,3-b]pyrazin-6-one as a brown solid (3.02 g).

Provenance & Evidence