Acetic Acid → HCID 66640999, compound

Participants

Reaction Steps

600 mg (1.7 mmol) of methyl 2-(2,6-dimethoxy-4-pentylphenyl)cyclohexane-carboxylate were dissolved in 10 ml of methanol, a solution of 200 mg (8.7 mmol) of sodium in 7.5 ml of methanol was added, and the mixture was heated under reflux overnight. The mixture was subsequently diluted with water, acidified using acetic acid and extracted with dichloromethane. The combined organic phases were dried over sodium sulfate, filtered and evaporated, giving 388 mg (75%) of methyl trans-2-(2,6-dimethoxy-4-pentyl-phenyl)cyclohexanecarboxylate as a colourless oil.

Provenance & Evidence