Dimethylformamide → HCID 59623738, compound

Participants

Reaction Conditions

Reaction Steps

To C-(2,4-dichloro-phenyl)-N-(2-fluoro-ethyl)-methanesulfonamide (Example 8.1) (0.231 g) was added successively 3-chloro-pyrazine-2-carboxylic acid methyl ester (0.151 g), potassium carbonate (0.446 g) and N,N-dimethylformamide (2 ml). The reaction mixture was heated in a microwave for 25 minutes at 120° C. The reaction mixture was diluted with ethyl acetate and washed with aqueous hydrochloric acid (2M). The organic extracts were dried over magnesium sulfate and concentrated. The residue was dissolved in acetonitrile (1 ml) and 4-dimethylaminopyridine (“DMAP”) (1 mg) and 2,2-dimethylpropionyl chloride (7 μl) were added. The reaction mixture was heated in a microwave at 120° C. for 25 minutes. The reaction mixture was concentrated and the residue purified by column chromatography on silica gel (eluent: ethyl acetate/hexane 15:85) to give Compound No. C58 of Table C (21 mg).

Provenance & Evidence