反应详情

A solution of the product obtained in Step E and sodium cyanide (0.225 g) in ethanol is heated at reflux for 72 hours. After evaporation to dryness, the residue is taken up in a mixture of CH2Cl2/water. The aqueous phase is extracted three times with CH2Cl2. The organic phases are combined. The organic phase is dried over magnesium sulphate, filtered and evaporated to dryness to yield the title product which is used directly in the next Step.

1. temperatureat reflux for 72 hours
2. customAfter evaporation to dryness
3. additionthe residue is taken up in a mixture of CH2Cl2/water
4. extractionThe aqueous phase is extracted three times with CH2Cl2
5. dry with materialThe organic phase is dried over magnesium sulphate
6. filtrationfiltered
7. customevaporated to dryness