反应详情

温度

40 °C

To a solution of the compound obtained in Step A (0.1448 mol) in glacial acetic acid (700 ml) there is added powdered zinc (0.8690 mol). The two-phase mixture is stirred at 40° C. for 8 hours. The reaction mixture is filtered and the filtrate is then evaporated to dryness. The residue is stirred in water overnight and filtered and the precipitate obtained is washed with water. The product is taken up in toluene and then evaporated to dryness, and is then taken up in ether, filtered, washed with ether and then dried in vacuo at 40° C. under P2O5 to yield the title product, which is used directly in the next Step.

1. filtrationThe reaction mixture is filtered
2. customthe filtrate is then evaporated to dryness
3. stirringThe residue is stirred in water overnight
4. filtrationfiltered
5. customthe precipitate obtained
6. washis washed with water
7. customevaporated to dryness
8. filtrationfiltered
9. washwashed with ether
10. customdried in vacuo at 40° C. under P2O5