HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Oxabicyclo(3.1.0)hexane-2,4-dione → (1R,5S)-3-(2-oxo-2,3-dihydro-1H-indol-5-ylmethyl)-3-aza-bicyclo[3.1.0]-hexane-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Oxabicyclo(3.1.0)hexane-2,4-dione | HCID 2734721 | — |
| Reactant | 5-(Aminomethyl)indolin-2-one | HCID 17982555 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | (1R,5S)-3-(2-oxo-2,3-dihydro-1H-indol-5-ylmethyl)-3-aza-bicyclo[3.1.0]-hexane-2,4-dione | HCID 66636255 | — |
Reaction Steps
A solution of the compound obtained in Step C (15 mmoles) and 3-oxa-bicyclo[3.1.0]-hexane-2,4-dione (22.5 mmoles) in acetic acid (60 ml) is heated at reflux for 48 hours. The mixture is brought to ambient temperature and the solid formed is filtered off to yield the title product, which is used directly in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08133889B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-496e977a69bf4de9909cb4a7cb1901ae |
| Source note | uspto-grants-2012_03 |