3-Methoxybenzyl bromide → HCID 25115528, compound

HRID 1094056Notes

Reaction equation

HRID 1094056 reaction equation
[NH2:1][C:2]1[C:3]([C:25]#[N:26])=[C:4]([C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=2[O:23][CH3:24])[C:5]2[C:10](=[O:11])[N:9]([CH3:12])[C:8](=[O:13])[N:7]([CH3:14])[C:6]=2[N:15]=1.Br[CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([O:35][CH3:36])[CH:30]=1>>[NH2:26][CH2:25][C:3]1[C:2]([NH:1][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([O:35][CH3:36])[CH:30]=2)=[N:15][C:6]2[N:7]([CH3:14])[C:8](=[O:13])[N:9]([CH3:12])[C:10](=[O:11])[C:5]=2[C:4]=1[C:16]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=1[O:23][CH3:24]

Participants

3

Reactant 2

HCID 40672073-Methoxybenzyl bromideHCID 59353132HCID 59353132, compound

Product 1

HCID 25115528HCID 25115528, compound

Procedure

The synthesis of title compounds started from Compound 70a and 1-(bromomethyl)-3-methoxybenzene, according to procedures described in the synthesis of Compound 56. MS [m+H] calc'd C25H27FN5O4 480; found 480.

Workup

  1. customThe synthesis of title compounds

Sources & evidence

ORD record
ord-a7e0cf24af7447fdbdb8d6027d3a995a
Source dataset
uspto-grants-2012_03
Patent number
US08133898B2

Reaction notes

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