1-(Bromomethyl)-2-(trifluoromethyl)benzene → HCID 25115295, compound

HRID 1094063Notes

Reaction equation

HRID 1094063 reaction equation
[NH2:1][C:2]1[C:3]([C:25]#[N:26])=[C:4]([C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=2[O:23][CH3:24])[C:5]2[C:10](=[O:11])[N:9]([CH3:12])[C:8](=[O:13])[N:7]([CH3:14])[C:6]=2[N:15]=1.Br[CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[C:35]([F:38])([F:37])[F:36].NCC1C(NCC2C=CC3C(=CC=CC=3)C=2)=NC2N(C)C(=O)N(C)C(=O)C=2C=1C1C=C(F)C=CC=1OC>>[NH2:26][CH2:25][C:3]1[C:2]([NH:1][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[C:35]([F:36])([F:37])[F:38])=[N:15][C:6]2[N:7]([CH3:14])[C:8](=[O:13])[N:9]([CH3:12])[C:10](=[O:11])[C:5]=2[C:4]=1[C:16]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=1[O:23][CH3:24]

Participants

4

Reactant 3

HCID 1230571-(Bromomethyl)-2-(trifluoromethyl)benzeneHCID 24970297HCID 24970297, compoundHCID 59353132HCID 59353132, compound

Product 1

HCID 25115295HCID 25115295, compound

Procedure

The synthesis of title compounds started from Compound 70a and 1-(bromomethyl)-2-(trifluoromethyl)benzene, according to procedures described in the synthesis of Compound 70. MS [m+H] calc'd C25H24FN5O3 518; found 518.

Workup

  1. customThe synthesis of title compounds

Sources & evidence

ORD record
ord-cffdec13898b4e1d888aef92987c9644
Source dataset
uspto-grants-2012_03
Patent number
US08133898B2

Reaction notes

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