Phenethyl bromide → HCID 59353151, compound

HRID 1094065Notes

Reaction equation

HRID 1094065 reaction equation
[NH2:1][C:2]1[C:3]([C:25]#[N:26])=[C:4]([C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=2[O:23][CH3:24])[C:5]2[C:10](=[O:11])[N:9]([CH3:12])[C:8](=[O:13])[N:7]([CH3:14])[C:6]=2[N:15]=1.Br[CH2:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[NH2:26][CH2:25][C:3]1[C:2]([NH:1][CH2:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[N:15][C:6]2[N:7]([CH3:14])[C:8](=[O:13])[N:9]([CH3:12])[C:10](=[O:11])[C:5]=2[C:4]=1[C:16]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=1[O:23][CH3:24]

Participants

3

Reactant 2

HCID 7666Phenethyl bromideHCID 59353132HCID 59353132, compound

Product 1

HCID 59353151HCID 59353151, compound

Procedure

The synthesis of title compounds started from Compound 70a (Example 64) and 1-(bromoethyl)benzene, according to procedures described in the synthesis of Compound 56. 1H NMR (400 MHz, CHLOROFORM-d) δ MS [m+H] calc'd C25H27FN5O3 464; found 464.

Workup

  1. customThe synthesis of title compounds

Sources & evidence

ORD record
ord-0476c40086bd49c195ca78bf3b9bc6e2
Source dataset
uspto-grants-2012_03
Patent number
US08133898B2

Reaction notes

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