1,4-Dioxane hydrochloride → HCID 66636838, compound

HRID 1094189Notes

Reaction equation

HRID 1094189 reaction equation
[CH:1]1([NH:7][C:8]2[CH:17]=[C:16]3[C:11]([C:12](=[O:35])[C:13]([NH:23][C:24](=[O:34])[CH2:25][NH:26]C(=O)OC(C)(C)C)=[CH:14][N:15]3[CH:18]([CH2:21][CH3:22])[CH2:19][CH3:20])=[CH:10][C:9]=2[F:36])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O1CCOCC1.[ClH:43]>O1CCOCC1>[ClH:43].[NH2:26][CH2:25][C:24]([NH:23][C:13]1[C:12](=[O:35])[C:11]2[C:16](=[CH:17][C:8]([NH:7][CH:1]3[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]3)=[C:9]([F:36])[CH:10]=2)[N:15]([CH:18]([CH2:21][CH3:22])[CH2:19][CH3:20])[CH:14]=1)=[O:34]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86633059HCID 86633059, compound

Product 1

HCID 66636838HCID 66636838, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a 2.9 ml dioxane solution of tert-butyl (2-{[7-(cyclohexylamino)-1-(1-ethylpropyl)-6-fluoro-4-oxo-1,4-dihydroquinolin-3-yl]amino}-2-oxoethyl)carbamate was added 3.0 ml of a 4M hydrogen chloride dioxane solution, followed by overnight stirring at room temperature. The insoluble materials were collected by filtration to obtain 550 mg of 2-amino-N-[7-(cyclohexylamino)-1-(1-ethylpropyl)-6-fluoro-4-oxo-1,4-dihydroquinolin-3-yl]acetamide hydrochloride.

Workup

  1. filtrationThe insoluble materials were collected by filtration

Sources & evidence

ORD record
ord-a34e9cfd535945cea7593ddba6bae0b3
Source dataset
uspto-grants-2012_03
Patent number
US08133882B2

Reaction notes

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