o-Phenylbenzoic acid → (R)-Biphenyl-2-yl-[3-(5-bromo-pyrimidin-2-ylamino)-piperidin-1-yl]-methanone

HRID 1094261Notes

Reaction equation

HRID 1094261 reaction equation
[C:1]1([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:2]([C:7]([OH:9])=O)=[CH:3][CH:4]=[CH:5][CH:6]=1.[Br:16][C:17]1[CH:18]=[N:19][C:20]([NH:23][C@@H:24]2[CH2:29][CH2:28][CH2:27][NH:26][CH2:25]2)=[N:21][CH:22]=1>>[C:1]1([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([N:26]1[CH2:27][CH2:28][CH2:29][C@@H:24]([NH:23][C:20]2[N:19]=[CH:18][C:17]([Br:16])=[CH:22][N:21]=2)[CH2:25]1)=[O:9]

Participants

3

Reactant 2

HCID 70357o-Phenylbenzoic acidHCID 66639492HCID 66639492, compound

Product 1

HCID 24968730(R)-Biphenyl-2-yl-[3-(5-bromo-pyrimidin-2-ylamino)-piperidin-1-yl]-methanone

Procedure

prepared by reaction of biphenyl-2-carboxylic acid with (R)-(5-bromo-pyrimidin-2-yl)-piperidine-3-yl-amine.

Sources & evidence

ORD record
ord-821a6bb669a342e1aab7be65d6c2f0d0
Source dataset
uspto-grants-2012_03
Patent number
US08133901B2

Reaction notes

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