2-(4-Methoxyphenyl)benzoic acid → (R)-[3-(5-Bromo-pyrimidin-2-ylamino)-piperidin-1-yl]-(4'-methoxy-biphenyl-2-yl)-methanone

HRID 1094262Notes

Reaction equation

HRID 1094262 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([C:15]([OH:17])=O)=[CH:11][CH:12]=[CH:13][CH:14]=2)=[CH:5][CH:4]=1.[Br:18][C:19]1[CH:20]=[N:21][C:22]([NH:25][C@@H:26]2[CH2:31][CH2:30][CH2:29][NH:28][CH2:27]2)=[N:23][CH:24]=1>>[Br:18][C:19]1[CH:20]=[N:21][C:22]([NH:25][C@@H:26]2[CH2:31][CH2:30][CH2:29][N:28]([C:15]([C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=3)=[O:17])[CH2:27]2)=[N:23][CH:24]=1

Participants

3

Reactant 2

HCID 2668302-(4-Methoxyphenyl)benzoic acidHCID 66639492HCID 66639492, compound

Product 1

HCID 24964474(R)-[3-(5-Bromo-pyrimidin-2-ylamino)-piperidin-1-yl]-(4'-methoxy-biphenyl-2-yl)-methanone

Procedure

prepared by reaction of 4′-methoxy-biphenyl-2-carboxylic acid with (R)-(5-bromo-pyrimidin-2-yl)-piperidine-3-yl-amine.

Sources & evidence

ORD record
ord-1b3111d0703f45579d0b4fba2cd068fc
Source dataset
uspto-grants-2012_03
Patent number
US08133901B2

Reaction notes

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