2-(3-fluorophenyl)benzoic Acid → (R)-[3-(5-Bromo-pyrimidin-2-ylamino)-piperidin-1-yl]-(3'-fluoro-biphenyl-2-yl)-methanone

HRID 1094264Notes

Reaction equation

HRID 1094264 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:9]([C:14]([OH:16])=O)=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1.[Br:17][C:18]1[CH:19]=[N:20][C:21]([NH:24][C@@H:25]2[CH2:30][CH2:29][CH2:28][NH:27][CH2:26]2)=[N:22][CH:23]=1>>[Br:17][C:18]1[CH:19]=[N:20][C:21]([NH:24][C@@H:25]2[CH2:30][CH2:29][CH2:28][N:27]([C:14]([C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=3[C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=3)=[O:16])[CH2:26]2)=[N:22][CH:23]=1

Participants

3

Reactant 2

HCID 27826842-(3-fluorophenyl)benzoic AcidHCID 66639492HCID 66639492, compound

Product 1

HCID 24968732(R)-[3-(5-Bromo-pyrimidin-2-ylamino)-piperidin-1-yl]-(3'-fluoro-biphenyl-2-yl)-methanone

Procedure

prepared by reaction of 3′-fluoro-biphenyl-2-carboxylic acid with (R)-(5-bromo-pyrimidin-2-yl)-piperidine-3-yl-amine.

Sources & evidence

ORD record
ord-8736cc41a0d34df5a847a0403b8fcee0
Source dataset
uspto-grants-2012_03
Patent number
US08133901B2

Reaction notes

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